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Plant-derived antimicrobials to fight against multi-drug-resistant human pathogens

Subramani, Ramesh and Narayanaswamy, Mathivanan and Feussner, Klaus D. (2017) Plant-derived antimicrobials to fight against multi-drug-resistant human pathogens. 3 BioTech, 7 . p. 172. ISSN 2190-5738

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Antibiotic resistance is becoming a pivotal concern for public health that has accelerated the search for new antimicrobial molecules from nature. Numbers of human pathogens have inevitably evolved to become resistant to various currently available drugs causing considerable mortality and morbidity worldwide. It is apparent that novel antibiotics are urgently warranted to combat these life-threatening pathogens. In recent years, there have been an increasing number of studies to discover new bioactive compounds from plant origin with the hope to control antibiotic-resistant bacteria. This review attempts to focus and record the plant-derived compounds and plant extracts against multi-drug-resistant (MDR) pathogens including methicillin-resistant Staphylococcus aureus (MRSA), MDR-Mycobacterium tuberculosis and malarial parasites Plasmodium spp. reported between 2005 and 2015. During this period, a total of 110 purified compounds and 60 plant extracts were obtained from 112 different plants. The plants reviewed in this study belong to 70 different families reported from 36 countries around the world. The present review also discusses the drug resistance in bacteria and emphasizes the urge for new drugs.

Item Type: Journal Article
Uncontrolled Keywords: Antibiotic resistance; MRSA; Medicinal plants; Plant metabolites
Subjects: Q Science > QD Chemistry
Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Science, Technology and Environment (FSTE) > Institute of Applied Science
Depositing User: Fulori Nainoca - Waqairagata
Date Deposited: 06 Jul 2017 02:35
Last Modified: 06 Jul 2017 04:43

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