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iPHLoc - ES: identification of bacteriophage protein locations using evolutionary and structural features

Shatabda, S. and Saha, S. and Sharma, Alokanand and Dehzangi, A. (2017) iPHLoc - ES: identification of bacteriophage protein locations using evolutionary and structural features. Journal of Theoretical Biology, 435 . pp. 229-237. ISSN 0022-5193

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Abstract

Bacteriophage proteins are viruses that can significantly impact on the functioning of bacteria and can be used in phage based therapy. The functioning of Bacteriophage in the host bacteria depends on its location in those host cells. It is very important to know the subcellular location of the phage proteins in a host cell in order to understand their working mechanism. In this paper, we propose iPHLoc-ES, a prediction method for subcellular localization of bacteriophage proteins. We aim to solve two problems: discriminating between host located and non-host located phage proteins and discriminating between the locations of host located protein in a host cell (membrane or cytoplasm). To do this, we extract sets of evolutionary and structural features of phage protein and employ Support Vector Machine (SVM) as our classifier. We also use recursive feature elimination (RFE) to reduce the number of features for effective prediction. On standard dataset using standard evaluation criteria, our method significantly outperforms the state-of-the-art predictor

Item Type: Journal Article
Subjects: Q Science > Q Science (General)
Divisions: Faculty of Science, Technology and Environment (FSTE) > School of Engineering and Physics
Depositing User: Ms Shalni Sanjana
Date Deposited: 15 Jan 2018 11:46
Last Modified: 15 Jan 2018 11:46
URI: http://repository.usp.ac.fj/id/eprint/10500
UNSPECIFIED

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