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Salicylic acid as an effective elicitor for improved taxol production in endophytic fungus Pestalotiopsis microspora

Subban, Kamalraj and Subramani, Ramesh and Srinivasan, Vishnu P.M. and Johnpaul, Muthumary and Chelliah, Jayabaskaran (2019) Salicylic acid as an effective elicitor for improved taxol production in endophytic fungus Pestalotiopsis microspora. PLoS ONE, 14 (2). NA. ISSN 1932-6203

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    Abstract

    Salicylic acid (SA) is an effective elicitor to increase taxol production in Pestalotiopsis microspora. Addition of SA at the concentration of 300 μM yielded taxol 625.47 μg L-1, 45- fold higher than that of the control. Elicitation of the role of SA in the fungal taxol biosynthetic pathway revealed that SA enhanced reactive oxygen species and lipid peroxidation of unsaturated fatty acids of P. microspora mycelia. This oxidative process stimulates isoprene biosynthetic pathway by triggering expression of the geranylgeranyl pyrophosphate synthase gene leading to improved biosynthesis of taxol in P. microspora.

    Item Type: Journal Article
    Subjects: Q Science > QH Natural history > QH301 Biology
    Divisions: Faculty of Science, Technology and Environment (FSTE) > School of Biological and Chemical Sciences
    Depositing User: Ms Shalni Sanjana
    Date Deposited: 26 Feb 2019 09:41
    Last Modified: 26 Feb 2019 09:41
    URI: http://repository.usp.ac.fj/id/eprint/11368
    UNSPECIFIED

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