Discovering MoRFs by trisecting intrinsically disordered protein sequence into terminals and middle regions

Sharma, Ronesh and Sharma, Alokanand and Patil, Ashwini and Tsunoda, Tatsuhiko (2019) Discovering MoRFs by trisecting intrinsically disordered protein sequence into terminals and middle regions. BMC Bioinformatics, 19 (13). pp. 155-163. ISSN 1471-2105

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Abstract

Background Molecular Recognition Features (MoRFs) are short protein regions present in intrinsically disordered protein (IDPs) sequences. MoRFs interact with structured partner protein and upon interaction, they undergo a disorder-to-order transition to perform various biological functions. Analyses of MoRFs are important towards understanding their function. Results Performance is reported using the MoRF dataset that has been previously used to compare the other existing MoRF predictors. The performance obtained in this study is equivalent to the benchmarked OPAL predictor, i.e., OPAL achieved AUC of 0.815, whereas the model in this study achieved AUC of 0.819 using TEST set. Conclusion Achieving comparable performance, the proposed method can be used as an alternative approach for MoRF prediction.

Item Type:	Journal Article
Subjects:	Q Science > Q Science (General) T Technology > T Technology (General)
Divisions:	Faculty of Science, Technology and Environment (FSTE) > School of Engineering and Physics
Depositing User:	Alokanand Sharma
Date Deposited:	02 Apr 2019 00:48
Last Modified:	02 Apr 2019 00:48
URI:	http://repository.usp.ac.fj/id/eprint/11401

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