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Antimalarial bromophycolides J-Q from the Fijian red alga Callophycus serratus

Lane, A.L. and Stout, E.P. and Lin, A.S. and Prudhomme, J. and Roch, K.L. and Fairchild, C.R. and Franzblau, S.G. and Hay, M.E. and Aalbersberg, William G.L. and Kubanek, J. (2009) Antimalarial bromophycolides J-Q from the Fijian red alga Callophycus serratus. The Journal of Organic Chemistry, 74 (7). pp. 2736-2742. ISSN 0022-3263

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Abstract

Bromophycolides J−Q (1−8) were isolated from extracts of the Fijian red alga Callophycus serratus and identified with 1D and 2D NMR spectroscopy and mass spectral analyses. These diterpene−benzoate macrolides represent two novel carbon skeletons and add to the 10 previously reported bromophycolides (9−18) from this alga. Among these 18 bromophycolides, several exhibited activities in the low micromolar range against the human malaria parasite Plasmodium falciparum.

Item Type: Journal Article
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Science, Technology and Environment (FSTE) > Institute of Applied Science
Depositing User: Ms Neha Harakh
Date Deposited: 24 May 2009 14:12
Last Modified: 12 Jul 2012 20:52
URI: http://repository.usp.ac.fj/id/eprint/1475
UNSPECIFIED

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