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Antibacterial Neurymenolides from the Fijian red alga Neurymenia fraxinifolia

Stout, E.P. and Hasemeyer, A.P. and Lane, A.L. and Davenport, T.M. and Engel, S. and Hay, M.E. and Fairchild, C.R. and Prudhomme, J. and Le Roch, K. and Aalbersberg, William G.L. and Kubanek, J. (2009) Antibacterial Neurymenolides from the Fijian red alga Neurymenia fraxinifolia. Organic Letters, 11 (1). pp. 225-228. ISSN 1523-7060

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Abstract

Two novel α-pyrone macrolides, neurymenolides A (1) and B (2), were isolated from the Fijian red alga Neurymenia fraxinifolia and characterized using a combination of NMR and mass spectral analyses. These molecules represent only the second example of α-pyrone macrolides, with 1 existing as interchanging atropisomers due to restricted rotation about the α-pyrone ring system. Neurymenolide A (1) displayed moderately potent activities against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistantEnterococcus faecium (VREF).

Item Type: Journal Article
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Science, Technology and Environment (FSTE) > Institute of Applied Science
Depositing User: Ms Neha Harakh
Date Deposited: 24 May 2009 14:12
Last Modified: 18 Jul 2012 19:08
URI: http://repository.usp.ac.fj/id/eprint/1506
UNSPECIFIED

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