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NF-κB-inhibiting Naphthopyrones from the Fijian echinoderm Comanthus parvicirrus

Folmer, F. and Harrison, W.T.A. and Tabudravu, Jioji N. and Jaspars, M. and Aalbersberg, William G.L. and Feussner, Klaus D. and Wright, Anthony D and Dicato, M. and Diederich, M. (2008) NF-κB-inhibiting Naphthopyrones from the Fijian echinoderm Comanthus parvicirrus. Journal of Natural Products, 71 (1). pp. 106-111. ISSN 0163-3864

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The two naphthopyrones 6-methoxycomaparvin (1) and 6-methoxycomaparvin 5-methyl ether (2) were isolated from a bioactive methanol-soluble extract of the Fijian echinoderm Comanthus parvicirrus. Their structures were assigned on the basis of spectroscopic methods. X-ray diffraction analysis was used to confirm the structure of 1. Both compounds were tested for their potential to inhibit the activation of the transcription factor NF-κB, which plays an important role in cancer development and inflammation, and the mechanism of action of the two compounds was investigated. Both naphthopyrones 1 and 2 completely inhibit TNF-α-induced NF-κB activation at a concentration of 300 µM by inhibiting the enzymatic activity of the kinase IKKβ.

Item Type: Journal Article
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Science, Technology and Environment (FSTE) > Institute of Applied Science
Depositing User: Ms Neha Harakh
Date Deposited: 11 Jan 2008 01:04
Last Modified: 03 Jul 2017 23:29

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