USP Electronic Research Repository

Antineoplastic unsaturated fatty acids from Fijian macroalgae

Jiang, R.W. and Hay, M.E. and Fairchild, C.R. and Prudhomme, J. and Roch, K.L. and Aalbersberg, William G.L. and Kubanek, J. (2008) Antineoplastic unsaturated fatty acids from Fijian macroalgae. Phytochemistry, 69 (13). pp. 2495-2500. ISSN 0031-9422

Full text not available from this repository.

Abstract

Phytochemical analysis of Fijian populations of the green alga Tydemania expeditionis led to the isolation of two unsaturated fatty acids, 3(zeta)-hydroxy-octadeca-4(E),6(Z),15(Z)-trienoic acid (1) and 3(zeta)-hydroxy-hexadeca-4(E),6(Z)-dienoic acid (2), along with the known 3(zeta)-hydroxy-octadeca-4(E),6(Z)-dienoic acid (4). Investigations of the red alga Hydrolithon reinboldii led to identification of a glycolipid, lithonoside (3), and five known compounds, 15-tricosenoic acid, hexacosa-5,9-dienoic methyl ester, beta-sitosterol, 10(S)-hydroxypheophytin A, and 10(R)-hydroxypheophytin A. The structures of 1-3 were elucidated by spectroscopic methods (1D and 2D NMR spectroscopy and ESI-MS). Compounds 1, 2, and 4, containing conjugated double bonds, demonstrated moderate inhibitory activity against a panel of tumor cell lines (including breast, colon, lung, prostate and ovarian cells) with IC(50) values ranging from 1.3 to 14.4 microM. The similar cell selectivity patterns of these three compounds suggest that they might act by a common, but unknown, mechanism of action.

Item Type: Journal Article
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Science, Technology and Environment (FSTE) > Institute of Applied Science
Depositing User: Ms Neha Harakh
Date Deposited: 11 Jan 2008 09:21
Last Modified: 10 Jul 2012 21:12
URI: http://repository.usp.ac.fj/id/eprint/183
UNSPECIFIED

Actions (login required)

View Item