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Bioactive bromophycolides R-U from the Fijian red alga Callophycus serratus

Lin, A.S. and Stout, E.P. and Prudhomme, J. and Le Roch, K. and Fairchild, C.R. and Franzblau, S.G. and Aalbersberg, William G.L. and Hay, M.E. and Kubanek, J. (2010) Bioactive bromophycolides R-U from the Fijian red alga Callophycus serratus. Journal of Natural Products, 73 (2). pp. 275-278. ISSN 0163-3864

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Abstract

Four new bromophycolides, R−U (1−4), were isolated from the Fijian red alga Callophycus serratus and were identified by 1D and 2D NMR and mass spectroscopic analyses. These compounds expand the known structural variety of diterpene-benzoate macrolides and exhibited modest cytotoxicity toward selected human cancer cell lines. Bromophycolide S (2) also showed submicromolar activity against the human malaria parasite Plasmodium falciparum.

Item Type: Journal Article
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Science, Technology and Environment (FSTE) > Institute of Applied Science
Depositing User: Ms Mereoni Camailakeba
Date Deposited: 24 May 2010 15:02
Last Modified: 12 Jul 2012 21:14
URI: http://repository.usp.ac.fj/id/eprint/1894
UNSPECIFIED

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