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Synthesis, spectral, and biological properties of copper(II) complexes of thiosemicarbazones of schiff bases derived from 4-aminoantipyrine and aromatic aldehydes

Agarwal, Ram K. and Singh, L. and Sharma, D.K. (2006) Synthesis, spectral, and biological properties of copper(II) complexes of thiosemicarbazones of schiff bases derived from 4-aminoantipyrine and aromatic aldehydes. Bioinorganic Chemistry and Applications, 59509 . pp. 1-10. ISSN 1565-3633

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Abstract

We have synthesized a novel series of Schiff bases by condensation of 4-aminoantipyrine and various aromatic aldehydes followed by reaction with thiosemicarbazide. These thiosemicarbazones are potential ligands toward transition metal ions. The reaction of copper(II) salts with 4[N-(benzalidene)amino]antipyrinethiosemicarbazone (BAAPTS), 4[N-(4′-methoxybenzalidene) amino] antipyrinethiosemicarbozone (MBAAPTS), 4[N-(4′-dimethylamino benzalidene) amino] antipyrinethiosemicarbazone (DABAAPTS), and 4[N-(cinnamalidene) amino] antipyrinethiosemicarbazone (CAAPTS) resulted in the formation of solid complexes with the general composition CuX2 • (H2O)(L)(X = Cl, Br,NO3,NCS, or CH3COO; L = BAAPTS, MBAAPTS, DABAAPTS, or CAAPTS). These complexes were characterized through elemental analysis, molecular weight, electrical conductance, infrared, electronic spectra, and magnetic susceptibilities at room temperature. Copper(II) complexes with BAAPTS and MBAAPTS were screened for antibacterial and antifungal properties and have exhibited potential activity. Thermal stabilities of two representative complexes were also investigated.

Item Type: Journal Article
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Science, Technology and Environment (FSTE) > School of Biological and Chemical Sciences
Depositing User: Ms Neha Harakh
Date Deposited: 16 Mar 2006 15:17
Last Modified: 10 May 2012 19:14
URI: http://repository.usp.ac.fj/id/eprint/3969
UNSPECIFIED

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