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Novel antineoplastic diterpene-benzoates from the Fijian red alga Callophycus serratus

Lane, A.L. and Prusak, A.C. and Hay, M.E. and Snell, T.W. and Giese, R.A. and Hardcastle, K. and Fairchild, C.R. and Aalbersberg, William G.L. and Raventos-Suarez, C. and Kubanek, J. (2006) Novel antineoplastic diterpene-benzoates from the Fijian red alga Callophycus serratus. Abstracts of Papers of the American Chemical Society, NA . pp. 231-270. ISSN 0065-7727

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Red macroalgae are well-known for the production of brominated metabolites, including terpenoids and phenols, yet some taxa within the Rhodophyta remain relatively unstudied. Herein, we report the discovery of unusual diterpene-benzoate natural products representing three novel carbon skeletons, from the red alga Callophycus serratus collected in Fiji. Included among the new compounds were 15- and 16-membered macrolides as well as non-macrocyclic diterpene-benzoic acid structural motifs, all apparently sharing the same 27-carbon biosynthetic precursor. Biological activities of these compounds included moderate antibacterial, antiviral, and antineoplastic effects via specific apoptotic cell death.

Item Type: Journal Article
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Science, Technology and Environment (FSTE) > Institute of Applied Science
Depositing User: Ms Neha Harakh
Date Deposited: 15 Mar 2006 21:59
Last Modified: 11 May 2012 05:04

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