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Fijimycins A-C, three antibacterial etamycin-class depsipetides from a marine-derived Streptomyces sp

Sun, P. and Maloney, K.N. and Nam, S.J. and Haste, N.M. and Raju, Ritesh and Aalbersberg, William G.L. and Jensen, P.R. and Nizet, V. and Hensler, M.E. and Fenical, W. (2011) Fijimycins A-C, three antibacterial etamycin-class depsipetides from a marine-derived Streptomyces sp. Bioorganic & Medicinal Chemistry, 19 (22). pp. 6557-6562. ISSN 0968-0896

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Abstract

Three new depsipeptides, fijimycins A–C (1–3), together with the known etamycin A (4), were isolated and identified from the fermentation broth of strain CNS-575, a Streptomyces sp. cultured from a marine sediment sample collected off Nasese, Fiji. The planar structures of the new fijimycins were assigned by combined interpretation of NMR and MS/MS spectroscopic data. These assignments were complicated by the fact that 1–3 occurred as complex amide conformational mixtures. The absolute configurations of the component amino acids were established using the Marfey’s method. Fijimycins A–C, and etamycin A, were shown to possess significant in vitro antibacterial activity against three methicillin-resistant Staphylococcus aureus (MRSA) strains with MIC100 values between 4 and 16 μg mL−1.

Item Type: Journal Article
Subjects: Q Science > Q Science (General)
Divisions: Faculty of Science, Technology and Environment (FSTE) > Institute of Applied Science
Depositing User: Ms Shalni Sanjana
Date Deposited: 25 Jun 2011 17:17
Last Modified: 25 Jun 2012 17:17
URI: http://repository.usp.ac.fj/id/eprint/4823
UNSPECIFIED

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