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Antineoplastic diterpene-benzoate macrolides from the Fijian red alga Callophycus serratus

Kubanek, J. and Prusak, A.C. and Hay, M.E. and Snell, T.W. and Giese, R.A. and Hardcastle, K. and Fairchild, C.R. and Aalbersberg, William G.L. and Raventos-Suarez, C. (2005) Antineoplastic diterpene-benzoate macrolides from the Fijian red alga Callophycus serratus. Organic Letters, 7 (23). pp. 5261-5264. ISSN 1523-7060

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Abstract

Three diterpene-benzoate natural products, with novel carbon skeletons and an unusual proposed biosynthesis, were isolated from extracts of the Fijian red alga Callophycus serratus and identified by a combination of X-ray crystallographic, NMR, and mass spectral analyses. Bromophycolide A (1) displayed cytotoxicity against several human tumor cell lines via specific apoptotic cell death. This represents the first discovery of natural products incorporating a diterpene and benzoate skeleton into a macrolide system.

Item Type: Journal Article
Subjects: Q Science > Q Science (General)
Divisions: Faculty of Science, Technology and Environment (FSTE) > Institute of Applied Science
Depositing User: Ms Shalni Sanjana
Date Deposited: 08 Aug 2005 14:44
Last Modified: 07 Oct 2013 10:11
URI: http://repository.usp.ac.fj/id/eprint/5071
UNSPECIFIED

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