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Aurantoside K, a new antifungal tetramic acid glycoside from a Fijian marine sponge of the genus Melophlus

Kumar, Rohitesh and Subramani, Ramesh and Feussner, Klaus D. and Aalbersberg, William G.L. (2012) Aurantoside K, a new antifungal tetramic acid glycoside from a Fijian marine sponge of the genus Melophlus. Marine Drugs, 10 (1). pp. 200-208. ISSN 1660-3397

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    Abstract

    A new tetramic acid glycoside, aurantoside K, was isolated from a marine sponge belonging to the genus Melophlus. The structure of the compound was elucidated on the basis of spectroscopic analysis (1H NMR, 1H–1H COSY, HSQC, and HMBC, as well as high-resolution ESILCMS). Aurantoside K did not show any significant activity in antimalarial, antibacterial, or HCT-116 cytotoxicity assays, but exhibited a wide spectrum of antifungal activity against wild type Candida albicans, amphotericin-resistant C. albicans, Cryptococcus neoformans, Aspergillus niger, Penicillium sp., Rhizopus sporangia and Sordaria sp.

    Item Type: Journal Article
    Uncontrolled Keywords: marine sponges; aurantosides; antifungal; tetramic acid glycoside; Melophlus sp
    Subjects: G Geography. Anthropology. Recreation > GC Oceanography
    Q Science > Q Science (General)
    Divisions: Faculty of Science, Technology and Environment (FSTE) > Institute of Applied Science
    Depositing User: Ms Shalni Sanjana
    Date Deposited: 05 Oct 2012 10:33
    Last Modified: 02 Aug 2016 12:35
    URI: http://repository.usp.ac.fj/id/eprint/5292
    UNSPECIFIED

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