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Conformational stability studies of a stapled hexa-β3-peptide library

Gopalan, Romila D. and Del Borgo, M.P. and Bergman, Y.E. and Unabia, S. and Mulder, R.J. and Wilce, M.C. and Wilce, J.A. and Aguilar, M.I. and Perlmutter, P. (2012) Conformational stability studies of a stapled hexa-β3-peptide library. Organic & Biomolecular Chemistry, 10 (9). pp. 1802-1806. ISSN 1477-0520

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Abstract

A library of 14-helical hexa β(3)-peptides was synthesized in order to determine the influence of sequence variation as well as staple size and location on conformational stability. From this study we show that appropriately stapled hexa-β(3)-peptides can allow for a number of variations without significant perturbation of the 14-helix.

Item Type: Journal Article
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Science, Technology and Environment (FSTE) > School of Biological and Chemical Sciences
Depositing User: Ms Shalni Sanjana
Date Deposited: 19 Dec 2012 13:03
Last Modified: 25 Jul 2016 15:22
URI: http://repository.usp.ac.fj/id/eprint/5325
UNSPECIFIED

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