USP Electronic Research Repository

Laxative potency of Methanolic extract of Sea Cucumber (Holothuria leucospilota): Avian Model (pigeons, Columbia livia)

Rofeta, J. and Christi, Ketan S. and Sotheeswaran, Subramaniam (2013) Laxative potency of Methanolic extract of Sea Cucumber (Holothuria leucospilota): Avian Model (pigeons, Columbia livia). [Conference Proceedings]

[img] PDF - Published Version
Restricted to Repository staff only

Download (267kB)
Official URL:


Marine organisms produce many secondary metabolites, which are commonly referred to as natural products. These organisms often exhibit unique chemical responses when they are under stress. Many of these chemicals may have medicinal applications. In this research work methanolic extract from the body wall of holothurian (Holothuria leucospilota) was studied in vivo to test its effect on passage rate of digesta using avian model. The effect of sea cucumber solvent extract (SCSE) was compared with a known laxative drug (bisacodyl) in 36 feral pigeons fed with various doses (5mg, 20mg, and 40mg) of the extract. Cloaca excretions were collected after administration of the treatments on hourly intervals for initial 6hrs, six hourly intervals for 42hrs and 12hrly interval for 102hrs. Observations on moisture content (%) and chromic oxide recovery (mg) were recorded from these samples. These parameters were used to determine the passage rate (mg/hr) of digesta along the gut for 102 hrs. Mean moisture content for birds fed with 40mg and known drug was relatively higher to other treatments. Results revealed a stimulatory effect of extract on the passage rate of digesta dry matter (mg/hr) and chromic oxide recovery rate (99% and 96%). SCSE of 40mg dose was comparable to the laxative drug. The results indicated that the holothurian extract has a laxative potency.

Item Type: Conference Proceedings
Uncontrolled Keywords: Holothurian extract, laxative, moisture content, chromic oxide recovery, avian model
Subjects: Q Science > QL Zoology
R Medicine > RM Therapeutics. Pharmacology
Divisions: Faculty of Science, Technology and Environment (FSTE) > School of Biological and Chemical Sciences
Depositing User: Ketan Christi
Date Deposited: 05 Aug 2013 21:24
Last Modified: 06 Jul 2016 01:03

Actions (login required)

View Item View Item

Document Downloads

More statistics for this item...