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κ-carrageenan, genipin and chitosan cross - linked composites for drug release in simulated gastrointestinal fluids

Raj, Kushaal and Lata, Roselyn A. and Rohindra, David (2016) κ-carrageenan, genipin and chitosan cross - linked composites for drug release in simulated gastrointestinal fluids. UNSPECIFIED.

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Abstract

κ-carrageenan was extracted from the red sea algae, Kappaphycus alvarezii using 0.1 and 0.3 M KOH. Blends for drug release were prepared by mixing varying amounts (20, 30 and 40 v/v %) of κ-carrageenan with chitosan and cross-linked with genipin. The optimal genipin concentration for the blend was determined by AFM and swelling studies. FT-IR showed that κ-carrageenan was immiscible with chitosan and hence mostly physical crosslinking had occurred. Swelling and drug release investigated in simulated gastrointestinal fluid (pH of 1.2, 4.5, 6.8) showed similar trends and were responsive to the ionic composition, pH of the media, and the amount of κ-carrageenan in the blend. Blends containing increasing amounts of κ-carrageenan, treated with 0.3 M KOH showed increased and faster drug release. The bio polymeric membranes were responsive to stimuli for the drug release and serves as a possible oral delivery route for Quetiapine fumarate.

Item Type: Other
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Science, Technology and Environment (FSTE) > School of Biological and Chemical Sciences
Depositing User: Ms Shalni Sanjana
Date Deposited: 22 Nov 2016 11:01
Last Modified: 22 Nov 2016 11:01
URI: http://repository.usp.ac.fj/id/eprint/9473
UNSPECIFIED

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