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Preparation of β - nitroalanine using the Easton three - component coupling method

Soapi, Katy M. and Hutton, C.A. (2006) Preparation of β - nitroalanine using the Easton three - component coupling method. Amino Acids, 31 (3). pp. 337-339. ISSN 0939-4451

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Abstract

A simple one-step preparation of β-nitroalanine has been developed using the Easton three-component coupling method. To date one limitation of this method has been that use of nitromethane as the nitroalkane component does not yield β-nitroalanine. We report that use of the dipotassium salt of nitroacetic acid in the Easton three-component coupling gives β-nitroalanine in high yield, presumably via facile decarboxylation of a β-nitroaspartate intermediate.

Item Type: Journal Article
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Science, Technology and Environment (FSTE) > School of Biological and Chemical Sciences
Depositing User: Repo Editor
Date Deposited: 15 Dec 2016 15:43
Last Modified: 15 Dec 2016 15:43
URI: http://repository.usp.ac.fj/id/eprint/9477
UNSPECIFIED

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