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Pseudochelin A, a siderophore of Pseudoalteromonas piscicida S2040

Sonnenschein, Eva C. and Stierhof, Marc and Goralczyk, Stephan and Vabre, Floriane M and Pellissier, Léonie and Hanssen, Kine Østnes and de la Cruz, Mercedes and Díaz, Caridad and de Witte, Peter and Copmans, Daniëlle and Andersen, Jeanette Hammer and Hansen, Espen and Kristoffersen, Venke and Tormo, José R. and Ebel, Rainer and Milne, Bruce F. and Deng, Hai and Gram, Lone and Jaspars, Marcel and Tabudravu, Jioji N. (2017) Pseudochelin A, a siderophore of Pseudoalteromonas piscicida S2040. Tetrahedron, 73 (18). pp. 2633-2637. ISSN 0040-4020

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A new siderophore containing a 4,5-dihydroimidazole moiety was isolated from Pseudoalteromonas piscicida S2040 together with myxochelins A and B, alteramide A and its cycloaddition product, and bromo- and dibromoalterochromides. The structure of pseudochelin A was established by spectroscopic techniques including 2D NMR and MS/MS fragmentation data. In bioassays selected fractions of the crude extract of S2040 inhibited the opportunistic pathogen Pseudomonas aeruginosa. Pseudochelin A displayed siderophore activity in the chrome azurol S assay at concentrations higher than 50 μM, and showed weak activity against the fungus Aspergillus fumigatus, but did not display antibacterial, anti-inflammatory or anticonvulsant activity.

Item Type: Journal Article
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Science, Technology and Environment (FSTE) > School of Biological and Chemical Sciences
Depositing User: Fulori Nainoca - Waqairagata
Date Deposited: 16 May 2017 23:45
Last Modified: 12 Feb 2021 03:59

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