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Tianchimycins A--B, 16-membered macrolides from the rare actinomycete Saccharothrix xinjiangensis

Wang, Xiaoling and Tabudravu, Jioji N. and Jaspars, Marcel and Deng, Hai (2013) Tianchimycins A--B, 16-membered macrolides from the rare actinomycete Saccharothrix xinjiangensis. Tetrahedron, 69 (30). pp. 6060-6064. ISSN 0040-4020

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Abstract

Two new 16-membered macrolactone-type polyketides, Tianchimycin A (1) and B (2), were isolated from the rare actinomycete Saccharothrix xinjiangensis NRRL B-24321, together with one known compound, swalpamycin B (3). The isolated compounds were structurally characterized using 1D and 2D NMR and MS techniques. The antimicrobial activities of 1–3 were determined against a panel of Gram-negative and Gram-positive bacteria including five hospital isolates from NHS Grampian. Compound 3 displayed moderate antibacterial activity against three MRSA clinical isolates and Enterococcus faecalis ATCC 29212.

Item Type: Journal Article
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Science, Technology and Environment (FSTE) > School of Biological and Chemical Sciences
Depositing User: Fulori Nainoca
Date Deposited: 18 May 2017 13:39
Last Modified: 04 Jul 2017 11:05
URI: http://repository.usp.ac.fj/id/eprint/9902
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