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The inhibition of TNF-α-induced NF-κB activation by marine natural products

Folmer, Florence and Jaspars, Marcel and Solano, Godofredo and Cristofanon, Silvia and Henry, Estelle and Tabudravu, Jioji N. and Black, Kenny and Green, David H. and Küpper , Frithjof C. and Aalbersberg, William G.L. and Feussner, Klaus D. and Dicato, Maria and Diederich, Marc (2009) The inhibition of TNF-α-induced NF-κB activation by marine natural products. Biochemical Pharmacology, 78 (6). pp. 592-606. ISSN 0006-2952

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Abstract

The deregulated activation of NF-κB is associated with cancer development and inflammatory diseases. With an aim to find new NF-κB inhibitors, we purified and characterized compounds from extracts of the Fijian sponge Rhabdastrella globostellata, the crinoid Comanthus parvicirrus, the soft corals Sarcophyton sp. nov. and Sinularia sp., and the gorgonian Subergorgia sp. after an initial screening of 266 extracts from different marine origins. Results obtained show that selected purified compounds had a cytotoxic effect on the human leukaemia cell line K562, inhibited both TNF-α-induced NF-κB-DNA binding as well as TNF-α-induced IκBα degradation and nuclear translocation of p50/p65. Furthermore, we observed the inhibition of NF-κB activation induced by an overexpression of IKKβ. Interestingly, natural products inhibited IKKβ kinase as well as the 26S proteasome proteolytic activity.

Item Type: Journal Article
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Science, Technology and Environment (FSTE) > School of Biological and Chemical Sciences
Depositing User: Fulori Nainoca
Date Deposited: 18 May 2017 14:09
Last Modified: 06 Jun 2017 10:19
URI: http://repository.usp.ac.fj/id/eprint/9905
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