USP Electronic Research Repository

Conformational studies of free and Li+ complexed jasplakinolide, a cyclic depsipeptide from the Fijian marine sponge Jaspis splendens

Tabudravu, Jioji N. and Morris, Linda A. and Milne, Bruce F. and Jaspars, Marcel (2005) Conformational studies of free and Li+ complexed jasplakinolide, a cyclic depsipeptide from the Fijian marine sponge Jaspis splendens. Organic & Biomolecular Chemistry, 3 (5). pp. 745-749. ISSN 1477-0520

Full text not available from this repository.

Abstract

The complexation of Li+ to jasplakinolide, a marine sponge derived cyclic depsipeptide showed preferential binding to two out of four carbonyl oxygens (C-10, C-14) and the electrons of the aromatic system of the β-tyrosine amino acid residue. This is in contrast to previous results obtained by others who proposed complexation to three out of four available carbonyl oxygens (C-1, C-10, C-14). The structure of the complex in CD3CN was determined by NOE restrained molecular dynamic calculations. Structures of the uncomplexed jasplakinolide were calculated in CDCl3 and CD3CN for comparison.

Item Type: Journal Article
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Science, Technology and Environment (FSTE) > School of Biological and Chemical Sciences
Depositing User: Repo Editor
Date Deposited: 06 Jun 2017 15:09
Last Modified: 04 Jul 2017 11:34
URI: http://repository.usp.ac.fj/id/eprint/9927
UNSPECIFIED

Actions (login required)

View Item