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Axinellin C, a proline-rich cyclic octapeptide isolated from the Fijian marine sponge Stylotella aurantium

Tabudravu, Jioji N. and Morris, Linda A. and den Bosch, J. Jantina Kettenes-van and Jaspars, Marcel (2002) Axinellin C, a proline-rich cyclic octapeptide isolated from the Fijian marine sponge Stylotella aurantium. Tetrahedron, 58 (39). 7863 - 7868. ISSN 0040-4020

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Abstract

The structure of a new cyclic octapeptide, axinellin C, (cyclo[Thr1-Val2-Pro3-Trp4-Pro5-Phe6-Pro7-Leu8]), with all-trans peptide bond geometry, was elucidated by a combination of 2D NMR methods and tandem mass spectrometry. The solution state conformation was determined by ROE restrained molecular dynamics calculations. The structural features were found to be similar to those of the crystal structure of the cyclic decapeptide, phakellistatin 8, despite differing peptide sequences.

Item Type: Journal Article
Additional Information: Supports Open Access
Uncontrolled Keywords: natural products; amino acids; peptides; Stylotella aurantium; sponge; nuclear magnetic resonance; mass spectrometry; restrained molecular dynamics; solution conformation
Subjects: Q Science > QD Chemistry
Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Science, Technology and Environment (FSTE) > School of Biological and Chemical Sciences
Depositing User: Repo Editor
Date Deposited: 06 Jun 2017 14:57
Last Modified: 06 Jun 2017 14:57
URI: http://repository.usp.ac.fj/id/eprint/9930
UNSPECIFIED

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