USP Electronic Research Repository

Psammaplin A, a chitinase inhibitor isolated from the fijian marine sponge Aplysinella rhax

Tabudravu, Jioji N. and Eijsink, V.G.H and Gooday, G.W. and Jaspars, M. and Komander, D. and Legg, M. and Synstad, B. and van Aalten, D.M.F. (2002) Psammaplin A, a chitinase inhibitor isolated from the fijian marine sponge Aplysinella rhax. Bioorganic & Medicinal Chemistry, 10 (4). 1123 - 1128. ISSN 0968-0896

Full text not available from this repository.

Abstract

Several brominated tyrosine derived compounds, psammaplins A (1), K (2) and L (3) as well as bisaprasin (4) were isolated from the Fijian marine sponge Aplysinella rhax during a bioassay guided isolation protocol. Their structures were determined using {NMR} and {MS} techniques. Psammaplin A was found to moderately inhibit chitinase B from Serratia marcescens, the mode of inhibition being non-competitive. Crystallographic studies suggest that a disordered psammaplin A molecule is bound near the active site. Interestingly, psammaplin A was found to be a potent antifungal agent.

Item Type: Journal Article
Subjects: Q Science > QD Chemistry
Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Science, Technology and Environment (FSTE) > School of Biological and Chemical Sciences
Depositing User: Repo Editor
Date Deposited: 06 Jun 2017 14:05
Last Modified: 04 Jul 2017 11:55
URI: http://repository.usp.ac.fj/id/eprint/9935
UNSPECIFIED

Actions (login required)

View Item