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Wainunuamide, a histidine-containing proline-rich cyclic heptapeptide isolated from the Fijian marine sponge Stylotella aurantium

Tabudravu, Jioji N. and Morris, Linda A. and Bosch, J.Jantina Kettenes-van den and Jaspars, Marcel (2001) Wainunuamide, a histidine-containing proline-rich cyclic heptapeptide isolated from the Fijian marine sponge Stylotella aurantium. Tetrahedron Letters, 42 (52). pp. 9273-9276. ISSN 0040-4039

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Abstract

The isolation and structure determination of an unusual cyclic heptapeptide, wainunuamide, from a Fijian marine sponge, Stylotella aurantium, is reported. The peptide contains three proline residues and a histidine residue, which is rare in cyclic peptides and has only previously been reported in a cyclic peptide isolated from the cyanobacterium Oscillatoria agardhii, suggesting a possible source of the peptide. Wainunuamide is found to have weak cytotoxic activity.

Item Type: Journal Article
Uncontrolled Keywords: sponges; cyclic peptides; NMR; MS; cytotoxicity
Subjects: Q Science > QD Chemistry
Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Science, Technology and Environment (FSTE) > School of Biological and Chemical Sciences
Depositing User: Repo Editor
Date Deposited: 06 Jun 2017 12:14
Last Modified: 04 Jul 2017 11:56
URI: http://repository.usp.ac.fj/id/eprint/9940
UNSPECIFIED

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