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NMR characterisation of natural products derived from under-explored microorganisms

Rateb, Mostafa E. and Tabudravu, Jioji N. and Ebel, Rainer (2016) NMR characterisation of natural products derived from under-explored microorganisms. In: Nuclear Magnetic Resonance. The Royal Society of Chemistry, London, United Kingdom, pp. 240-268. ISBN 978-1-78262-053-2

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Abstract

Microbial natural products has drawn a great attention from both academia and industry. Obtaining the planar, relative, and possibly the absolute configuration of such novel metabolites requires considerable efforts. In this chapter, the general NMR experiments that were traditionally used, and the recently introduced pulse sequences that provide more precise output in significantly shorter times, and applicable to high throughput screening are discussed. Additionally, various dereplication approaches that allow tracking of new metabolites were highlighted. Lastly, the power of CASE in the structural identification and confirmation of manually-elucidated molecules using selected examples from our research projects was demonstrated.

Item Type: Book Chapter
Additional Information: PDF eISBN: 978-1-78262-410-3 EPUB eISBN: 978-1-78262-869-9 DOI:10.1039/9781782624103-00240
Subjects: Q Science > QD Chemistry
Q Science > QH Natural history > QH301 Biology
Q Science > QR Microbiology > QR180 Immunology
Divisions: Faculty of Science, Technology and Environment (FSTE) > School of Biological and Chemical Sciences
Depositing User: Repo Editor
Date Deposited: 06 Jun 2017 12:05
Last Modified: 06 Jun 2017 12:05
URI: http://repository.usp.ac.fj/id/eprint/9946
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