Lane, A.L. and Prusak, A.C. and Hay, M.E. and Snell, T.W. and Giese, R.A. and Hardcastle, K. and Fairchild, C.R. and Aalbersberg, William G.L. and Raventos-Suarez, C. and Kubanek, J. (2006) Novel antineoplastic diterpene-benzoates from the Fijian red alga Callophycus serratus. Abstracts of Papers of the American Chemical Society, NA . pp. 231-270. ISSN 0065-7727
Full text not available from this repository.Abstract
Red macroalgae are well-known for the production of brominated metabolites, including terpenoids and phenols, yet some taxa within the Rhodophyta remain relatively unstudied. Herein, we report the discovery of unusual diterpene-benzoate natural products representing three novel carbon skeletons, from the red alga Callophycus serratus collected in Fiji. Included among the new compounds were 15- and 16-membered macrolides as well as non-macrocyclic diterpene-benzoic acid structural motifs, all apparently sharing the same 27-carbon biosynthetic precursor. Biological activities of these compounds included moderate antibacterial, antiviral, and antineoplastic effects via specific apoptotic cell death.
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Faculty of Science, Technology and Environment (FSTE) > Institute of Applied Science |
| Depositing User: | Ms Neha Harakh |
| Date Deposited: | 15 Mar 2006 21:59 |
| Last Modified: | 11 May 2012 05:04 |
| URI: | http://repository.usp.ac.fj/id/eprint/4013 |
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