Kubanek, J. and Prusak, A.C. and Hay, M.E. and Snell, T.W. and Giese, R.A. and Hardcastle, K. and Fairchild, C.R. and Aalbersberg, William G.L. and Raventos-Suarez, C. (2005) Antineoplastic diterpene-benzoate macrolides from the Fijian red alga Callophycus serratus. Organic Letters, 7 (23). pp. 5261-5264. ISSN 1523-7060
Full text not available from this repository.Abstract
Three diterpene-benzoate natural products, with novel carbon skeletons and an unusual proposed biosynthesis, were isolated from extracts of the Fijian red alga Callophycus serratus and identified by a combination of X-ray crystallographic, NMR, and mass spectral analyses. Bromophycolide A (1) displayed cytotoxicity against several human tumor cell lines via specific apoptotic cell death. This represents the first discovery of natural products incorporating a diterpene and benzoate skeleton into a macrolide system.
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > Q Science (General) |
| Divisions: | Faculty of Science, Technology and Environment (FSTE) > Institute of Applied Science |
| Depositing User: | Ms Shalni Sanjana |
| Date Deposited: | 08 Aug 2005 02:44 |
| Last Modified: | 06 Oct 2013 22:11 |
| URI: | http://repository.usp.ac.fj/id/eprint/5071 |
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