Bromophycoic Acids: Bioactive natural products from a Fijian red alga Callophycus sp.

Teasdale, M.E. and Shearer, T.L. and Engel, S. and Alexander, T.S. and Fairchild, C.R. and Prudhomme, J. and Torres, M. and Le Roch, K. and Aalbersberg, William G.L. and Hay, M.E. and Kubanek, J. (2012) Bromophycoic Acids: Bioactive natural products from a Fijian red alga Callophycus sp. The Journal of Organic Chemistry, 77 (18). pp. 8000-8006. ISSN 0022-3263

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Abstract

Bioassay-guided fractionation of extracts from a Fijian red alga in the genus Callophycus resulted in the isolation of five new compounds of the diterpene-benzoate class. Bromophycoic acids A"12E (1"125) were characterized by NMR and mass spectroscopic analyses and represent two novel carbon skeletons, one with an unusual proposed biosynthesis. These compounds display a range of activities against human tumor cell lines, malarial parasites, and bacterial pathogens including low micromolar suppression of MRSA and VREF.

Item Type:	Journal Article
Subjects:	Q Science > QD Chemistry
Divisions:	Faculty of Science, Technology and Environment (FSTE) > Institute of Applied Science
Depositing User:	Ms Shalni Sanjana
Date Deposited:	02 Sep 2013 03:40
Last Modified:	19 Jan 2017 00:48
URI:	http://repository.usp.ac.fj/id/eprint/6476

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