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Three bioactive sesquiterpene quinones from the Fijian marine sponge of the genus Hippospongia

Kumar, Rohitesh and Subramani, Ramesh and Aalbersberg, William G.L. (2012) Three bioactive sesquiterpene quinones from the Fijian marine sponge of the genus Hippospongia. Natural Product Research . pp. 1-4. ISSN 1478-6419

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    A sesquiterpenoid quinone, epi-ilimaquinone (1), and two sesquiterpene amino quinones, smenospongine (2) and glycinylilimaquinone (3), were isolated from the Fijian marine spongeHippospongia sp. The structures of these compounds were determined by spectroscopic analysis. Compounds 1 and 3 were reported for the first time in this study from the sponge of the genusHippospongia. Compound 1 displayed potent cytotoxic activity and showed antibacterial activity against methicillin-resistant Staphylococcus aureus, wild type S. aureus and vancomycin-resistantEnterococcus faecium and displayed antifungal activity against amphotericin-resistant Candida albicans while compounds 2 and 3 showed moderate cytotoxic activity. However, compound 1 did not show appreciable antifungal activity against wild type C. albicans, Cryptococcus neoformans,Aspergillus niger, Penicillium sp., Rhizopus sporangia or Sordaria sp.

    Item Type: Journal Article
    Subjects: S Agriculture > SH Aquaculture. Fisheries. Angling
    Divisions: Faculty of Science, Technology and Environment (FSTE) > Institute of Applied Science
    Depositing User: Ms Shalni Sanjana
    Date Deposited: 03 Oct 2012 12:47
    Last Modified: 02 Aug 2016 12:33

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