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New antiplasmodial Bromotyrosine derivatives from Suberea ianthelliformis Lendenfeld, 1888

Mani, Luke and Jullian, V. and Mourkazel, B. and Valentin, A. and Dubois, J. and Cresteil, T. and Folcher, E. and Hooper, J.N.A. and Erpenbeck, D. and Aalbersberg, William G.L. and Debitus, C. (2012) New antiplasmodial Bromotyrosine derivatives from Suberea ianthelliformis Lendenfeld, 1888. Chemistry & Biodiversity, 9 (8). pp. 1436-1451. ISSN 1612-1872

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    Four samples of Suberea ianthelliformis were investigated and furnished five new and 13 known brominated tyrosine-derived compounds. Two of the new compounds were identified as araplysillin N20-formamide and its N-oxide derivative. Three other new compounds, araplysillins IV, V, and VI, were isolated and identified as analogs of araplysillin II. Most of these compounds exhibit moderate inhibitory activities against chloroquine-resistant and -sensitive strains of Plasmodium falciparum, and were investigated for their PFTase inhibitory properties. The chemical content of the investigated sponges is correlated with their molecular phylogeny.

    Item Type: Journal Article
    Subjects: G Geography. Anthropology. Recreation > GC Oceanography
    Q Science > QD Chemistry
    Divisions: Faculty of Science, Technology and Environment (FSTE) > Institute of Applied Science
    Depositing User: Ms Shalni Sanjana
    Date Deposited: 03 Oct 2012 12:46
    Last Modified: 03 Oct 2012 12:46

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