Tadesse, Marg and Tabudravu, Jioji N. and Jaspars, Marcel and Str, Morten B. and Hansen, Espen and Andersen, Jeanette Hammer and Kristiansen, Per E. and Haug, Tor (2011) The antibacterial ent-eusynstyelamide B and eusynstyelamides D, E, and F from the Arctic bryozoan Tegella cf. spitzbergensis. Journal of Natural Products, 74 (4). pp. 837-841. ISSN 0163-3864
Full text not available from this repository. (Request a copy)Abstract
The brominated tryptophan-derived ent-eusynstyelamide B (1) and three new derivatives, eusynstyelamides D, E, and F (2−4), were isolated from the Arctic bryozoan Tegella cf. spitzbergensis. The structures were elucidated by spectroscopic methods including 1D and 2D NMR and analysis of mass spectrometric data. The enantiomer of 1, eusynstyelamide B, has previously been isolated from the Australian ascidian Eusynstyela latericius. Antimicrobial activities are here reported for 1−4, with minimum inhibitory concentrations (MIC) as low as 6.25 μg/mL for 1 and 4 against Staphylococcus aureus. Eusynstyelamides 2 and 3 showed weak cytotoxic activity against the human melanoma A 2058 cell line.
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Faculty of Science, Technology and Environment (FSTE) > School of Biological and Chemical Sciences |
| Depositing User: | Fulori Nainoca - Waqairagata |
| Date Deposited: | 18 May 2017 02:02 |
| Last Modified: | 03 Jul 2017 23:21 |
| URI: | http://fjrepository.usp.ac.fj/id/eprint/9904 |
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