Genomic insights into specialized metabolism in the marine actinomycete Salinispora

Letzel, Anne-Catrin and Li, Jing and Amos, Gregory C. A. and Millán-Aguiñaga, Natalie and Ginigini, Joape and Abdelmohsen, Usama R. and Gaudêncio, Susana P. and Ziemert, Nadine and Moore, Bradley S. and Jensen, Paul R. (2017) Genomic insights into specialized metabolism in the marine actinomycete Salinispora. Environmental Microbiology, 19 (9). pp. 3660-3673. ISSN 1462-2912

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Abstract

Comparative genomics is providing new opportunities
to address the diversity and distributions of
genes encoding the biosynthesis of specialized
metabolites. An analysis of 119 genome sequences
representing three closely related species of the
marine actinomycete genus Salinispora reveals
extraordinary biosynthetic diversity in the form of 176
distinct biosynthetic gene clusters (BGCs) of which
only 24 have been linked to their products. Remarkably,
more than half of the BGCs were observed in
only one or two strains, suggesting they were
acquired relatively recently in the evolutionary history
of the genus. These acquired gene clusters are
concentrated in specific genomic islands, which represent
hot spots for BGC acquisition. While most
BGCs are stable in terms of their chromosomal position,
others migrated to different locations or were
exchanged with unrelated gene clusters suggesting a
plug and play type model of evolution that provides a
mechanism to test the relative fitness effects of specialized metabolites. Transcriptome analyses were
used to address the relationships between BGC
abundance, chromosomal position and product discovery.
The results indicate that recently acquired
BGCs can be functional and that complex evolutionary
processes shape the micro-diversity of
specialized metabolism observed in closely related
environmental bacteria.

Item Type:	Journal Article
Subjects:	Q Science > QD Chemistry
Divisions:	Faculty of Science, Technology and Environment (FSTE) > Institute of Applied Science
Depositing User:	Fulori Nainoca - Waqairagata
Date Deposited:	26 Mar 2018 02:55
Last Modified:	26 Mar 2018 02:55
URI:	https://repository.usp.ac.fj/id/eprint/10628

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