Multibiomarker interactions to diagnose and follow-up chronic exposure of a marine crustacean to hazardous and noxious substances (HNS)

Abreu, Isabel Oliveira and Monteiro , Catarina and Rocha, Cristina and Reis-Henriques, Maria Armanda and Teixeira , Catarina and Basto, Maria Clara and Ferreira, Marta and Almeida, C MArisa and Oliva-Teles, Luis and Guimaraes, Laura (2018) Multibiomarker interactions to diagnose and follow-up chronic exposure of a marine crustacean to hazardous and noxious substances (HNS). Environmental Pollution, 242 . pp. 1137-1145. ISSN 0269-7491

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Abstract

Integrated compensatory responses of physiological systems towards homeostasis are generally overlooked
when it comes to analysing alterations in biochemical parameters indicative of such processes.
Here an hypothesis-driven multivariate analysis accounting for interactive multibiomarker responses
was used to investigate effects of long-term exposure of Carcinus maenas to Hazardous and Noxious
Substances (HNS). Adult male crabs were exposed to low and high post-spill levels of acrylonitrile (ACN)
or aniline (ANL) for 21d. Bioaccumulation, feeding behaviour, and biomarkers related to mode-of-action
(MoA) (detoxification, neurotransmission and energy production) were evaluated over time. Distinct
temporal patterns of response to low and high exposure concentrations were depicted, with a main set of
interactive multibiomarker predictors identified for each HNS (five for ACN and three for ANL), useful to
follow coupled evolvement of biomarker responses. ACN caused peripheral neurotoxic effects coupled
with enhanced biotransformation and significant oxidative damage particularly relevant in gills. ANL
elicited alterations in central neurotransmission affecting ventilation coupled with very low levels of
oxidative damage in gills. Results indicate chronic toxicity data are determinant to improve HNS hazard
assessment if the aim is to obtain reliable risk calculations, and develop effective predictive models
avoiding overestimation but sufficiently protective. Accounting for multibiomarker interactions brought
otherwise overlooked information about C. maenas responses and MoA of ACN and ANL.

Item Type:	Journal Article
Subjects:	Q Science > Q Science (General)
Divisions:	Faculty of Science, Technology and Environment (FSTE) > School of Marine Studies
Depositing User:	Marta Ferreira
Date Deposited:	27 Aug 2018 02:40
Last Modified:	27 Aug 2018 02:40
URI:	https://repository.usp.ac.fj/id/eprint/10972

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