Fabrication of α‑Fe2O3 Nanostructures: synthesis, characterization, and their promising application in the treatment of Carcinoma A549 Lung Cancer Cells

Kumar, Indresh and Nayak, Rashmi and Chaudhary, Lal B. and Pandey, Vashist N. and Mishra, Sheo K. and Singh, Narendra K. and Srivastava, Abhishek and Prasad, Surendra and Naik, Radhey M. (2022) Fabrication of α‑Fe2O3 Nanostructures: synthesis, characterization, and their promising application in the treatment of Carcinoma A549 Lung Cancer Cells. ACS Omega, 7 (25). pp. 21882-21890. ISSN 2470-1343

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Abstract

In the present work, iron nanoparticles were synthesized in the α-Fe2O3 phase with the reduction of potassium hexachloroferrate(III) by using l-ascorbic acid as a reducing agent in the presence of an amphiphilic non-ionic polyethylene glycol surfactant in an aqueous solution. The synthesized α-Fe2O3 NPs were characterized by powder X-ray diffraction, field emission scanning electron microscopy, transmission electron microscopy, atomic force microscopy, dynamic light scattering, energy dispersive X-ray spectroscopy, Fourier transform infrared spectroscopy, and ultraviolet–visible spectrophotometry. The powder X-ray diffraction analysis result confirmed the formation of α-Fe2O3 NPs, and the average crystallite size was found to be 45 nm. The other morphological studies suggested that α-Fe2O3 NPs were predominantly spherical in shape with a diameter ranges from 40 to 60 nm. The dynamic light scattering analysis revealed the zeta potential of α-Fe2O3 NPs as −28 ± 18 mV at maximum stability. The ultraviolet–visible spectrophotometry analysis shows an absorption peak at 394 nm, which is attributed to their surface plasmon vibration. The cytotoxicity test of synthesized α-Fe2O3 NPs was investigated against human carcinoma A549 lung cancer cells, and the biological adaptability exhibited by α-Fe2O3 NPs has opened a pathway to biomedical applications in the drug delivery system. Our investigation confirmed that l-ascorbic acid-coated α-Fe2O3 NPs with calculated IC50 ≤ 30 μg/mL are the best suited as an anticancer agent, showing the promising application in the treatment of carcinoma A549 lung cancer cells.

Item Type:	Journal Article
Subjects:	Q Science > QD Chemistry
Divisions:	School of Agriculture, Geography, Environment, Ocean and Natural Sciences (SAGEONS)
Depositing User:	Ms Shalni Sanjana
Date Deposited:	20 Sep 2022 00:33
Last Modified:	20 Sep 2022 00:33
URI:	https://repository.usp.ac.fj/id/eprint/13686

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