Ng, J.C. and Xia, Q. and Muthusamy, S. and Lal, Vincent V. and Peng, C. (2019) Interaction of polyaromatic hydrocarbons and metals on bioaccessibility and toxicity of arsenic. In: Environmental Arsenic in a Changing World. CRC Press, London. ISBN 9781351046633
Full text not available from this repository.Abstract
We investigated the interaction effects of cadmium, lead and four PAHs on the toxicity of arsenic and each other. A simulated in vitro human digestive system and human liver cell-based assays were employed to determine their respective bioaccessibility, uptake and toxicity of individual toxicants and mixtures of up to all seven chemicals. Under most environmental conditions, additive effect can be assumed when assessing bioaccessibility of mixed arsenic, cadmium and lead with or without polyaromatic hydrocarbons whilst hepatic uptake was less than additive for cadmium mixed with arsenic/lead/pyrene/benzo[a]pyrene. Toxicity in HepG2 cells including cytotoxicity, oxidative stress, genotoxicity and AhR (aryl hydrocarbon receptor) activation were determined. The interaction amongst mixtures vary depending on toxic endpoints, concentration and number of individual chemicals in the mixtures. Therefore, the traditional concentration addition or independent action model for health risk assessment may over or under estimate the risk of mixtures. This study has gained understanding of mixture interaction and helps to refine current risk assessment of mixed contaminants.
| Item Type: | Book Chapter |
|---|---|
| Subjects: | Q Science > QD Chemistry T Technology > TP Chemical technology |
| Divisions: | School of Agriculture, Geography, Environment, Ocean and Natural Sciences (SAGEONS) |
| Depositing User: | Ms Shalni Sanjana |
| Date Deposited: | 24 Mar 2024 23:44 |
| Last Modified: | 24 Mar 2024 23:44 |
| URI: | https://repository.usp.ac.fj/id/eprint/14546 |
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