Folmer, F. and Harrison, W.T.A. and Tabudravu, Jioji N. and Jaspars, M. and Aalbersberg, William G.L. and Feussner, Klaus D. and Wright, Anthony D and Dicato, M. and Diederich, M. (2008) NF-κB-inhibiting Naphthopyrones from the Fijian echinoderm Comanthus parvicirrus. Journal of Natural Products, 71 (1). pp. 106-111. ISSN 0163-3864
Full text not available from this repository.Abstract
The two naphthopyrones 6-methoxycomaparvin (1) and 6-methoxycomaparvin 5-methyl ether (2) were isolated from a bioactive methanol-soluble extract of the Fijian echinoderm Comanthus parvicirrus. Their structures were assigned on the basis of spectroscopic methods. X-ray diffraction analysis was used to confirm the structure of 1. Both compounds were tested for their potential to inhibit the activation of the transcription factor NF-κB, which plays an important role in cancer development and inflammation, and the mechanism of action of the two compounds was investigated. Both naphthopyrones 1 and 2 completely inhibit TNF-α-induced NF-κB activation at a concentration of 300 µM by inhibiting the enzymatic activity of the kinase IKKβ.
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Faculty of Science, Technology and Environment (FSTE) > Institute of Applied Science |
| Depositing User: | Ms Neha Harakh |
| Date Deposited: | 11 Jan 2008 01:04 |
| Last Modified: | 03 Jul 2017 23:29 |
| URI: | https://repository.usp.ac.fj/id/eprint/171 |
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