A novel antibacterial and antifungal phenolic compound from the endophytic fungus Pestalotiopsis mangiferae

Subban, K. and Subramani, Ramesh and Johnpaul, M. (2012) A novel antibacterial and antifungal phenolic compound from the endophytic fungus Pestalotiopsis mangiferae. Natural Product Research, iFirst . pp. 1-5. ISSN 1478-6419

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Abstract

A novel phenolic compound, 4-(2,4,7-trioxa-bicyclo[4.1.0]heptan-3-yl) phenol (1), was isolated from Pestalotiopsis mangiferae, an endophytic fungus associated with Mangifera indica Linn. The structure of the compound was elucidated on the basis of comprehensive spectral analysis (UV, IR, 1H-, 13C- and 2D-NMR, as well as HRESI–MS). Compound (1) shows potent antibacterial and antifungal activity against Bacillus subtilis, Klebsiella pneumoniae, Escherichia coli, Micrococcus luteus, Pseudomonas aeruginosa and Candida albicans. The transmission electron microscope study for the mode of inhibition of compound (1) on bacterial pathogens revealed the destruction of bacterial cells by cytoplasm agglutination with the formation of pores in cell wall membranes.

Item Type:	Journal Article
Subjects:	Q Science > QR Microbiology
Divisions:	Faculty of Science, Technology and Environment (FSTE) > Institute of Applied Science
Depositing User:	Ms Shalni Sanjana
Date Deposited:	29 Jan 2013 03:25
Last Modified:	19 Jan 2017 00:36
URI:	https://repository.usp.ac.fj/id/eprint/5497

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