New cytotoxic callipeltins from the Solomon Island marine sponge Asteropus sp.

Stierhof, Marc and Hansen, Kine Østnes and Sharma, Mukesh K. and Feussner, Klaus D. and Subko, Karolina and Díaz-Rullo , Fernando F. and Isaksson, Johan and Perez-Victoria , Ignacio and Clarke, David and Hansen, Espen and Jaspars, Marcel and Tabudravu, Jioji N. (2016) New cytotoxic callipeltins from the Solomon Island marine sponge Asteropus sp. Tetrahedron, 72 . pp. 6929-6934. ISSN 0040-4020

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Abstract

Four new callipeltin A derivatives (NeQ) have been isolated from the Solomon Island marine sponge
Asteropus sp. Their structures were established by spectroscopic techniques followed by acid hydrolysis
and derivatisation of the free amino acids, and subsequent LCMS analysis of the derivatives. The compounds were evaluated for their activity against cancer cell lines A2058 (melanoma), HT-29 (colorectal
adenocarcinoma) and MCF-7 (breast adenocarcinoma) and non-malignant MRC-5 fibroblast cells. While
the acyclic callipeltins P and Q were inactive the cyclic callipeltins N and O showed significant cytotoxicity
against all exposed cell lines with IC50 values as low as 0.16 mM confirming the role of cyclic configuration in biological activity.

Item Type:	Journal Article
Subjects:	G Geography. Anthropology. Recreation > GE Environmental Sciences Q Science > Q Science (General) Q Science > QD Chemistry
Divisions:	Faculty of Science, Technology and Environment (FSTE) > Institute of Applied Science
Depositing User:	Fulori Nainoca - Waqairagata
Date Deposited:	24 Oct 2016 22:39
Last Modified:	04 Oct 2017 23:19
URI:	https://repository.usp.ac.fj/id/eprint/9434

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