Raj, Kushaal and Lata, Roselyn A. and Rohindra, David (2016) κ-carrageenan, genipin and chitosan cross - linked composites for drug release in simulated gastrointestinal fluids. UNSPECIFIED.
Full text not available from this repository.Abstract
κ-carrageenan was extracted from the red sea algae, Kappaphycus alvarezii using 0.1 and 0.3 M KOH. Blends for drug release were prepared by mixing varying amounts (20, 30 and 40 v/v %) of κ-carrageenan with chitosan and cross-linked with genipin. The optimal genipin concentration for the blend was determined by AFM and swelling studies. FT-IR showed that κ-carrageenan was immiscible with chitosan and hence mostly physical crosslinking had occurred. Swelling and drug release investigated in simulated gastrointestinal fluid (pH of 1.2, 4.5, 6.8) showed similar trends and were responsive to the ionic composition, pH of the media, and the amount of κ-carrageenan in the blend. Blends containing increasing amounts of κ-carrageenan, treated with 0.3 M KOH showed increased and faster drug release. The bio polymeric membranes were responsive to stimuli for the drug release and serves as a possible oral delivery route for Quetiapine fumarate.
| Item Type: | Other |
|---|---|
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Faculty of Science, Technology and Environment (FSTE) > School of Biological and Chemical Sciences |
| Depositing User: | Ms Shalni Sanjana |
| Date Deposited: | 21 Nov 2016 22:01 |
| Last Modified: | 21 Nov 2016 22:01 |
| URI: | https://repository.usp.ac.fj/id/eprint/9473 |
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