Kyeremeh, Kwaku and Acquah, Kojo Sekyi and Camas, Mustafa and Tabudravu, Jioji N. and Houssen, Wael and Deng, Hai and Jaspars, Marcel (2014) Butrepyrazinone, a new pyrazinone with an unusual methylation pattern from a Ghanaian Verrucosispora sp. K51G. Marine Drugs, 12 (10). pp. 5197-5208. ISSN 1660-3397
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Abstract
We report the structural characterization of a new pyrazinone analogue; butrepyrazinone, which was isolated from a new actinomycete strain Verrucosispora sp. K51G recovered from Ghanaian mangrove river sediment. Spectroscopy-guided fractionation led to the isolation of a compound from the fermentation culture and a combination of NMR spectroscopy, high-resolution mass spectrometry and computer-aided calculations revealed that butrepyrazinone (10) possesses an unusual methylation pattern on the pyrazinone ring. Butrepyrazinone (10), however, displayed no antibacterial activity against Gram-positive S. aureus ATCC 25923, the Gram-negative E. coli ATCC 25922 and a panel of clinical isolates of methicillin-resistant S. aureus (MRSA) strains, suggesting that 10 may act as a signal molecule for this strain. Although the same molecule has been synthesized previously, this is the first report to disclose the discovery of butrepyrazinone (10) from nature.
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Faculty of Science, Technology and Environment (FSTE) > School of Biological and Chemical Sciences |
| Depositing User: | Fulori Nainoca - Waqairagata |
| Date Deposited: | 17 May 2017 22:09 |
| Last Modified: | 05 Jun 2017 22:18 |
| URI: | https://repository.usp.ac.fj/id/eprint/9899 |
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