Kyeremeh, Kwaku and Acquah, Kojo Sekyi and Sazak, Anil and Houssen, Wael E. and Tabudravu, Jioji N. and Deng, Hai and Jaspars, Marcel (2014) Butremycin, the 3-hydroxyl derivative of ikarugamycin and a protonated aromatic tautomer of 5'-methylthioinosine from a Ghanaian Micromonospora sp. K310. Marine Drugs, 12 (2). pp. 999-1012. ISSN 1660-3397
Full text not available from this repository. (Request a copy)Abstract
A new actinomycete strain Micromonospora sp. K310 was isolated from Ghanaian mangrove river sediment. Spectroscopy-guided fractionation led to the isolation of two new compounds from the fermentation culture. One of the compounds is butremycin (2) which is the (3-hydroxyl) derivative of the known Streptomyces metabolite ikarugamycin (1) and the other compound is a protonated aromatic tautomer of 5′-methylthioinosine (MTI) (3). Both new compounds were characterized by 1D, 2D NMR and MS data. Butremycin (2) displayed weak antibacterial activity against Gram-positive S. aureus ATCC 25923, the Gram-negative E. coli ATCC 25922 and a panel of clinical isolates of methicillin-resistant S. aureus (MRSA) strains while 3 did not show any antibacterial activity against these microbes.
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Faculty of Science, Technology and Environment (FSTE) > School of Biological and Chemical Sciences |
| Depositing User: | Fulori Nainoca - Waqairagata |
| Date Deposited: | 17 May 2017 22:14 |
| Last Modified: | 03 Jul 2017 22:17 |
| URI: | https://repository.usp.ac.fj/id/eprint/9900 |
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