Urbaniak, Michael D. and Tabudravu, Jioji N. and Msaki, Aichi and Matera, Kathy Mansfield and Brenk, Ruth and Jaspars, Marcel and Ferguson, Michael A.J. (2006) Identification of novel inhibitors of UDP-Glc 4′-epimerase, a validated drug target for african sleeping sickness. Bioorganic & Medicinal Chemistry Letters, 16 (22). 5744 - 5747. ISSN 0960-894X
Full text not available from this repository. (Request a copy)Abstract
Novel inhibitors of Trypanosoma brucei and mammalian UDP-Glc 4′-epimerase were identified by screening a small library of natural products and commercially available drug-like molecules. The inhibitors possess low micromolar potency against the T. brucei and human enzymes in vitro, display a degree of selectivity between the two enzymes, and are cytotoxic to cultured T. brucei and mammalian cells.
| Item Type: | Journal Article |
|---|---|
| Additional Information: | Journal Supports Open Access |
| Uncontrolled Keywords: | Trypanosome |
| Subjects: | Q Science > QD Chemistry R Medicine > R Medicine (General) |
| Divisions: | Faculty of Science, Technology and Environment (FSTE) > School of Biological and Chemical Sciences |
| Depositing User: | Repo Editor |
| Date Deposited: | 09 Jun 2017 00:00 |
| Last Modified: | 09 Jun 2017 00:00 |
| URI: | https://repository.usp.ac.fj/id/eprint/9925 |
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