Tabudravu, Jioji N. and Eijsink, V.G.H and Gooday, G.W. and Jaspars, M. and Komander, D. and Legg, M. and Synstad, B. and van Aalten, D.M.F. (2002) Psammaplin A, a chitinase inhibitor isolated from the fijian marine sponge Aplysinella rhax. Bioorganic & Medicinal Chemistry, 10 (4). 1123 - 1128. ISSN 0968-0896
Full text not available from this repository. (Request a copy)Abstract
Several brominated tyrosine derived compounds, psammaplins A (1), K (2) and L (3) as well as bisaprasin (4) were isolated from the Fijian marine sponge Aplysinella rhax during a bioassay guided isolation protocol. Their structures were determined using {NMR} and {MS} techniques. Psammaplin A was found to moderately inhibit chitinase B from Serratia marcescens, the mode of inhibition being non-competitive. Crystallographic studies suggest that a disordered psammaplin A molecule is bound near the active site. Interestingly, psammaplin A was found to be a potent antifungal agent.
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > QD Chemistry Q Science > QH Natural history > QH301 Biology |
| Divisions: | Faculty of Science, Technology and Environment (FSTE) > School of Biological and Chemical Sciences |
| Depositing User: | Repo Editor |
| Date Deposited: | 06 Jun 2017 02:05 |
| Last Modified: | 03 Jul 2017 23:55 |
| URI: | https://repository.usp.ac.fj/id/eprint/9935 |
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